"when i was thinking of becoming a pro at the age of 29, i did not understand the meaning of shooting wildlife completely,” photographer takayuki meakawa said. he characterized his shooting technique as immature. but while following polar bears in northern canada for three weeks, he realized he could empathize with the animals. “i was so moved when i saw their maternal love was so deep,” he said.
since then, his work, as he describes it, is an attempt to show the animals’ spirits. he typically decides on a species and researches it before heading into the wild. he then goes to a place where the animal is likely to be and settles there, waiting ten hours a day for as long as a month before getting a shot that best captures the animal.
(steve bloom has a similar series on maternal polar bear affection)
Human brain specimen with glioblastoma multiforme.
Brain Cancer Cells Hide While Drugs Seek
Tumor cells temporarily lose mutation to evade drugs targeting mutation
A team of scientists, led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine, has found that brain cancer cells resist therapy by dialing down the gene mutation targeted by drugs, then re-amplify that growth-promoting mutation after therapy has stopped.
The findings are published in the December 5, 2013 online issue of Science.
“This discovery has considerable clinical implications because if cancer cells can evade therapy by a ‘hide-and-seek’ mechanism, then the current focus (of drug therapies) is unlikely to translate into better outcomes for patients,” said Mischel.
In recent years, new cancer therapies have emerged that target tell-tale gene mutations to identify specific cancer cells for destruction. Unfortunately, a variety of “resistance mechanisms” have also emerged, among them incomplete target suppression, second-site mutations and activation of alternative kinases or enzymes that maintain growth-promoting signals to the cancer itself.
“Most research is aimed at developing better drugs or better drug combinations to suppress these downstream signals,” Mischel said. “However, one thing that has not been carefully considered is whether cancer cells can modulate the levels of – and thus their dependence on – the target of the drug, evade therapy, and then re-acquire the oncogene to promote tumor growth when the drug is withdrawn.”
Holy crap that is fascinating!
As an avid reader of both comics and mythology it often annoys me that there seems to be some animosity towards Marvel’s Thor from a lot of Pagans. Often they refer to their Thor as the “real Thor” and disregard the comic hero as “fake”. A notion I find funny considering pantheistic Paganism is…
Look at you shitting on peoples beliefs, you go tiger… so edgy.
I’m not even going to bother telling you what’s wrong with all this fucking nonsense you’re spewing because we both know it’s not going to change your small minded bullshit one way or the other, but I’ll say this… you have some serious growing up to do, you condescending arse.